Cancer Biology and MicroRNAs Essay Example | Topics and Well Written Essays - 500 words

Cancer Biology and Microribonucleic acids - Essay ExampleThese various RNAs then decide how the amino acids testament be coded to make the final protein chain and hence the expression of the genes. MicroRNAs however, are non-coding which means that they are not involved in the transcription and the translation knead in any way. They are small molecules and they contain about twenty to twenty-five nucleotides. The role of the micro RNAs is to regulate gene expression as the move of the coding RNA needs to be streamlined to avoid abnormal or wrong coding. They are also very primal in RNA silencing which involves suppressing the effect of a gene or more than one gene after coding has taken place (Dutta & Lee, 2010). This can also be important in the elimination of certain unwanted genes form the body. RNA silencing involves the use of antisense RNA which is used in the gene silencing. The identification of the two were among the greatest kit and caboodle done in this field in the l ast century. Of more importance is the realization that miRNA were significant players in the etiology of cancer. Further studies have shown that the miRNAs can be used in cancer therapy and so understanding their nature existence and roles is of great importance to molecular biology. miRNAs are often expressed differently in various stages of development in the organism an aspect that made them be called small temporal RNA due to their temporary expression (Dutta & Lee, 2010). The techniques used to pulsation their expression include Northern blotting and primer extension assay. This has been developed to help in understanding the small aspects of DNA and RNA that scientists could have ignored or bypassed in the past. As highlighted earlier, micro RNAs play a role in suppressing target messenger RNA expression. This is a complex interaction which includes interacting with 3UTR in the mRNA. What has been noted is that there are many mismatches in the micro RNA target sites a situat ionthat is still being probed to establish the cause and cause in gene mRNA expression. miRNA is also known to inhibit or decrease the target levels in the respective mRNA and so this can cloak the organism adversely or serve as a predisposing factor for cancer.